Retatrutide is a medication in development, particularly for the treatment of obesity. It acts as a triple-agonist, meaning it targets and activates three different hormone receptors: GLP-1, GIP, and glucagon receptors.
Lyophilized powder
Purity - 99.9%
Volume - 20mg/vial
Mechanism of Action & Potential Benefits:
By activating these receptors, retatrutide can influence several metabolic processes, including:
Appetite regulation:Increased satiety and reduced hunger drive.
Increased energy expenditure:Potentially due to glucagon receptor activation.
Improved glucose homeostasis:Leading to better blood sugar control.
Fat metabolism:Potential benefits in fat metabolism, enhancing the effects of GLP-1 and GIP.
Cardiometabolic markers:Potential improvements in cardiovascular risk factors and markers of insulin resistance.
Metabolic dysfunction-associated steatotic liver disease (MASLD):Studies suggest it can significantly reduce liver fat.
Clinical Trial Results (Phase 2):
In a Phase 2 trial of adults with obesity or overweight, retatrutide demonstrated substantial weight loss.
At 48 weeks, the highest dose (12 mg) resulted in a mean weight reduction of 24.2%, or approximately 58 pounds.
Significant weight reduction of 5% or more was achieved in a high percentage of participants, especially at higher doses.